Human Clinical Trials for Bimagrumab Lowered Body Fat Percentage in Patients

Steven Heymsfield, MD took his research into phase II of randomized clinical trials and have just published their results. Heymsfield and his colleagues at the Pennington Biomedical Research Center at Louisiana State University have been researching bimagrumab – a monoclonal antibody with the ability to block activin type II receptors. This process promotes skeletal growth and results showed a reduction in total body fat mass.

The trials involved adults with type 2 diabetes or obesity. In this trial, patients did not eat less than before and still experienced weight loss. The results were similar to those seen when patients with obesity took appetite suppressing medications to reduce food intake. The fact that the patients did not change eating habits but still had reduced body fat mass following the 48 week trial suggests that there might be a completely new mechanism at play. Now, Heymsfield has to evaluate the potential future paths his bimagrumab might take.

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